Tendon Healing: Mechanical Loading, Microdamage and Gene Expression
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چکیده
...................................................................................................................................................... 1 POPULÄRVETENSKAPLIG SAMMANFATTNING ............................................................................ 2 LIST OF PAPERS ............................................................................................................................................ 3 INTRODUCTION ............................................................................................................................................ 4 AIM AND HYPOTHESIS .............................................................................................................................. 6 COMMENTS ON MATERIALS AND METHODS ................................................................................. 7 STUDY DESIGNS ............................................................................................................................................ 9 SUMMARY OF THE RESULTS ................................................................................................................ 11 Mechanical testing ................................................................................................................................... 11 Gene expression ....................................................................................................................................... 12 DISCUSSION .................................................................................................................................................. 14 Different loading conditions have different effects on healing tendons ........................... 14 Full loading affects inflammation in healing tendons .............................................................. 15 Full loading cause microdamage thereby stimulating tendon healing ............................... 17 Mechanotransduction and microdamage stimulates tendon healing differently ......... 18 Comparison with other studies ......................................................................................................... 19 CONCLUSION ................................................................................................................................................ 22 FUTURE ........................................................................................................................................................... 23 ACKNOWLEDGEMENTS ........................................................................................................................... 24 REFERENCES ................................................................................................................................................. 25
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تاریخ انتشار 2018